Agentic CRM: Complete Guide + TOP 5 Agentic CRM Software

Updated on
September 25, 2025
14 min read

Creatio: Agentic CRM to Create, Predict & Automate

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    Large enterprises have long relied on CRMs to connect with customers, centralize customer data, and align sales, marketing, and service teams. But businesses that use legacy CRM systems have struggled to transform scattered records into a single source of truth to enable better collaboration and insight. The good news is that the business landscape has evolved, and so have the CRM capabilities businesses may use.

    We are now entering the next era of CRM, where platforms don’t merely store and organize information; they can act on it. Agentic CRM platforms, those with AI at its core, enable business users to build and use AI-driven agents to analyze data in real time, predict customer needs, and take autonomous action, boosting productivity and improving business outcomes.

    In this article, we’ll explore what agentic CRM is, discover key use cases and measurable benefits, and compare the top five agentic CRM solutions that are shaping the future of customer relationship management.

    Key Takeaways:

    • Agentic CRM is the next evolution of customer relationship management, powered by autonomous AI agents that can interpret data, collaborate, and act autonomously.
    • By adopting agentic CRM platforms, large and medium sized businesses can boost revenue, shorten sales cycles, eliminate manual data entry, and deliver hyper-personalized experiences.
    • With AI and CRM converging rapidly, agentic platforms are poised to become a cornerstone of modern business.
    • Leading solutions such as Creatio, Salesforce, Microsoft, HubSpot, and Zoho showcase how agentic CRM is already reshaping the market and setting the standard for the future.

    What is an Agentic CRM?

    Agentic CRM is a customer relationship management system with built-in agentic AI that uses intelligent, autonomous agents to automate tasks and processes. While some agentic CRM platforms were built in the modern era and already have an agentic core, legacy CRMs are in a state of rapid modernization and patching agentic AI into their older architectures while they invest significant capital in building new AI capabilities from the ground up. In agentic CRM, AI agents must be an integral part of the software; they need access to and must holistically understand all the CRM objects, workflows, and relationships natively

    An agentic CRM doesn’t just store information or automate predefined steps like a traditional CRM. Instead, it actively analyzes data, makes real-time decisions, and takes autonomous actions to improve customer engagement and operational efficiency. 

    Agentic automation is not simply another technology trend. It is the foundation of how enterprises will innovate, compete, and grow in the AI Economy.
    Burley Kawasaki
    Global VP of Product Marketing and Strategy, Creatio

    How Does Agentic CRM Work?

    Agentic CRM operates like an intelligent digital organization. At its core is the main AI orchestrator that acts as the strategic brain, supported by a network of role-based CRM AI agents. These agents communicate, collaborate, and execute tasks much like a coordinated human team, only faster and at scale.

    The main AI orchestrator

    The main AI in the agentic CRM serves as the command center, interpreting business objectives, translating them into smaller, manageable tasks, and delegating them to the appropriate AI agent.

    Here’s a step-by-step breakdown of how the main AI operates:

    • Strategic planning - receives a goal from human users, analyzes it, and formulates a plan to fulfill the objectives in the most effective and efficient way. AI can also come up with the goals itself based on core strategic objectives, ask human supervisors for feedback, and proceed with fulfilling them.
    • Data gathering and analysis - collects data necessary to fulfill the goals, such as customer and market data, and analyzes it to obtain a full picture.
    • Task allocation - breaks objectives into smaller tasks and delegates them to the right AI agents.
    • Oversight and governance - monitors progress, enforces compliance rules, and dynamically reallocates resources when conditions change.

    Role-based AI agents

    Specialized AI-powered agents in the agentic CRM platform handle distinct responsibilities under the main AI’s direction. Each agent is built with domain-specific expertise and can, depending on AI governance settings, either act autonomously or request approval from human managers.

    In the agentic CRM platform, common agents include:

    • Sales agent - scores leads based on predefined criteria, automatically sends personalized outreach messages to the most promising prospects, and alerts the sales team when prospects show buying intent.
    • Marketing agent - designs and optimizes personalized marketing campaigns, generates marketing content, revises ad spend, and monitors campaign performance, adjusting campaign materials and channels to maximize ROI.
    • Customer service agent - provides round-the-clock support, answering frequently asked questions and performing simple tasks on behalf of customers, surfaces data that customer service agents need to resolve cases, and prepares knowledge base articles.
    • Analytics agent - generates dashboards and reports automatically, analyzes key data, and provides performance enhancement recommendations.

    Advanced agentic CRM systems also provide industry-specific AI agents trained to handle tasks unique to particular sectors. For example, a financial AI agent specializes in fraud detection and real-time risk assessment, while a healthcare agent focuses on patient engagement and regulatory compliance.

    Discover more AI agents examples across various functions and industries.

    Multi-agent collaboration

    For more complex tasks, the main AI orchestrator may deploy not only one, but a whole team of AI agents, which work together to fulfill a certain goal. This is called a multi-agent system and is the most advanced form of agentic AI.

    An agentic CRM platform enables autonomous AI agents to share data in real time and communicate with each other without any additional setups or connectors. If a task requires different AI agents to collaborate, the system’s central orchestrator dynamically coordinates their roles, allowing them to exchange context, delegate subtasks, and execute a unified agentic workflow from start to finish. This multi-agent system enables complex, cross-department workflows to run seamlessly without manual intervention.

    For example, the marketing AI agent can inform the sales AI agent when a prospect engages with a campaign, triggering immediate follow-up tasks.

    Feedback and continuous learning

    A defining strength of an agentic CRM is its ability to learn and adapt with every interaction. After each action, the system evaluates the outcome and user feedback and sends the results back into its central intelligence. This continuous feedback loop allows the main AI to refine its models, update predictive algorithms, and adjust decision-making strategies in real time.

    Because the learning is ongoing and automated, the agentic CRM platform evolves alongside the business and its customers, ensuring that recommendations and actions remain relevant even as market conditions, consumer preferences, and internal processes change. The result is a self-optimizing platform that grows smarter and more effective with each cycle.

    Benefits of Agentic CRM

    Adopting an agentic CRM platform brings organizations measurable advantages across customer experience, operations, and business growth.

    Increased productivity

    By delegating repetitive or analytical tasks to AI agents, teams spend less time on manual work and more on strategic initiatives. While agentic CRM executes time-consuming tasks, such as updating databases, scoring leads, or answering customer inquiries, humans can focus on creative aspects of their work, ultimately boosting their productivity.

    Smarter decision-making

    Agentic CRM software analyses data in real time and continuously learn from feedback, enabling smarter decisions. Businesses can make decisions based on current data, leading to more accurate forecasting and improved operations.

    Scalable growth

    Agentic CRM seamlessly adapts as data volumes, client numbers, users, and business processes expand. It supports growing teams and customer bases without performance loss. Over time, an agentic CRM system can orchestrate increasingly complex workflows, maintaining speed, reliability, and personalization as the organization scales.

    Continuous improvement

    Built-in feedback loops mean the agentic system continuously learns from every outcome. It gets smarter over time, improving recommendations, refining workflows, and adapting to changing market conditions without manual reprogramming.

    Competitive advantage

    Organizations that leverage autonomous, multi-agent intelligence can respond faster to market shifts and customer signals, outpacing competitors that rely on traditional, manual CRM systems.

    Proactive customer engagement

    Because it anticipates needs and acts autonomously, an agentic CRM engages customers at the right time with the right message - improving customer satisfaction, loyalty, and lifetime value.

    Dynamic adaptability

    Agentic CRM continuously senses changes in customer behavior or market conditions and adjusts its strategies on the fly - whether that means shifting outreach timing, reallocating campaign budgets, or refining product recommendations without human intervention.

    Shorter sales cycles

    An agentic CRM system instantly qualifies leads, prioritizes outreach, and personalizes follow-ups. This removes bottlenecks in the sales process, enabling sales teams to close deals faster and boost sales growth.

    Marketing acceleration

    Built-in marketing intelligence helps marketing professionals create hyper-personalized campaigns, perform real-time A/B testing, and automatically reallocate budgets across channels. Leveraging agentic CRM capabilities in marketing enables organizations to increase customer engagement and return on marketing spend.

    5 Best Agentic CRM Software

    The CRM landscape is rapidly evolving as AI moves from a supporting feature to the core of customer relationship management. Below are five standout AI-powered solutions that embody these agentic capabilities, offering businesses powerful tools to automate decisions, personalize customer interactions, and scale seamlessly.

    1. Creatio

    Creatio is an agentic CRM and workflow platform with AI and no-code at its core. AI and AI agents are embedded across the whole platform and can natively understand all CRM objects, workflows, and relationships. Creatio agentic CRM drives new levels of speed and agility, empowering teams to move faster, focus on creativity, and drive unprecedented results. Creatio.ai is at the heart of the platform and is not an add-on wrapped around a legacy solution.

    Creatio Agentic CRM

    Thanks to a unified platform that combines AI agents and no-code applications, Creatio enables humans and digital talents to work together in harmony. Creatio's AI agents are domain-specific digital assistants built into every layer of Creatio's platform that understand, act, and learn in a business environment. They are personalized to individual roles and work styles and can be customized with no code to handle specific workflows and access levels. By adapting to specific roles, AI agents can execute multi-step tasks and support informed decision-making, augmenting employees' productivity and efficiency.

    Creatio provides pre-built and customizable AI agents for sales, marketing, and customer service teams. These include agents such as content generation agents, account research agents, customer support agents, and many more. At the same time, Creatio offers its users access to enterprise-grade CRM business applications, such as customer 360, lead management, sales forecasting, case management, etc. The strength of Creatio agentic CRM lies in the combination of AI agents and no-code applications in one unified platform at a lower cost that allows customization with IT oversight, not IT dependency.

    Key features:

    • Conversational interface - allows users to use natural language to navigate through the agentic CRM.
    • Embedded experience - Creatio’s AI agents are seamlessly integrated with productivity tools like Teams, Outlook, Zoom, etc.
    • No-code capabilities - visual tools and natural language enable users to modify existing and deploy new CRM workflows in a matter of minutes without technical knowledge.
    • Unified AI automation - predictive, generative, and agentic automation in one cohesive platform enables smarter decisions.
    • AI Command Center - enables rapid creation and customization of AI Agents and AI Skills with natural language and no-code visual tools.
    • Role-based and vertical AI agents – Creatio provides AI agents tailored to fulfill tasks specific to certain departments as well as industries, like finance.
    • Sales automation - helps sales reps streamline the sales process and close deals faster.
    • Marketing automation - supports marketers in delivering personalized experiences at scale.
    • Customer Service automation - helps the customer service representatives resolve issues fast and keep customers happy with intelligent service tools.

    Pros:

    • AI agents are a core part of the platform with no extra licenses or hidden fees.
    • Flexibility and user-friendliness are enabled by a unique combination of AI and no-code tools.
    • Strong security measures and AI governance.
    • Built-in compliance with data protection laws and industry regulations.
    • An extensive marketplace with over 700 applications that expand Creatio's agentic CRM capabilities.
    • Industry-specific workflows and AI agents that provide out-of-the-box capabilities.
    • 70% faster implementation with no-code tools, prebuilt templates, and integrations.
    • 37% lower total cost of ownership, deployment, infrastructure, and maintenance.

    Cons:

    • Slight learning curve due to extensive capabilities and customization options.

    Rating:

    G2: 4.8/5

    Agentic Creatio CRM
    Unify your sales, service, marketing and ops with one agentic CRM
    Creatio CRM banner

    2. Salesforce Agentforce

    Salesforce’s Agentforce is an agentic layer on top of Salesforce’s existing CRM system. It supports building and deploying autonomous agents across sales, service, marketing, and commerce. Pre-built actions, industry templates, and integrations allow enterprises to scale AI agent usage while retaining governance and visibility. It’s especially strong for organizations already using Salesforce and seeking a mature ecosystem of apps, data, and integrations.

    Salesforce Agentforce

    Salesforce Agentforce combines predictive AI, generative AI, and AI agents, enabling businesses to solve issues faster, deliver more personalized experiences, and work smarter. Organizations can build and customize AI agents to support their employees with tasks such as lead follow-ups, content generation, and case management.

    Key features:

    • Artificial Intelligence - enables the creation of customizable, predictive, and generative AI experiences.
    • Sales Cloud - helps boost sales productivity with AI capabilities that range from lead qualification to forecasting and deal closing.
    • Service Cloud - streamlines processes, automation, and service operations with AI to improve customer experiences and engagement.
    • Marketing Cloud - helps improve engagement and build relationships with autonomous capabilities.
    • Commerce Cloud - combines automation with AI to simplify setting up digital shops and driving sales.

    Pros:

    • A comprehensive set of features, including AI-powered automation, omnichannel support, real-time data insights, and self-service options.
    • Seamlessly connects with Salesforce products.
    • Low-code tools enable users to build and customize solutions with less coding and technical expertise.

    Cons:

    • Steep learning curve for new users.
    • AI capabilities are not natively embedded and come at an extra cost.
    • Configuration and advanced customizations require technical skills or technical support.
    • Some users experienced a slowdown in performance when handling large data sets.
    • Very high costs of ownership and ongoing maintenance with advanced features tied to higher-tier licenses.

    Rating:

    G2: 4.5/5

    See also: Salesforce Alternatives & Competitors and Salesforce Marketing Cloud Alternatives & Competitors

    3. Microsoft Dynamics 365

    Microsoft Dynamics 365 incorporates agentic features through tools like Copilot Studio and domain-specific AI agents for sales, service, and finance. The platform provides autonomous agents such as the Customer Intent Agent and Sales Chat Agent, along with actionable insights and adaptive workflow automation. It’s a good choice for enterprises wanting robust security and seamless integration with the rest of their Microsoft stack.

    Microsoft Copilot AI Tool

    Microsoft Dynamics 365 helps businesses connect teams, processes, and data across the whole organization to increase operational efficiency and provide consistent customer experiences. With AI and relevant insights, businesses can better understand their customers, personalize journeys, and close more deals.

    Key features:

    • Microsoft Copilot - an agentic AI tool enhances productivity by automating repetitive tasks such as document creation, data analysis, and email management.
    • Copilot Chat - enables the creation of AI-driven agents that connect to an organization's data sources and automate business processes.
    • Copilot in Word - integrates work data directly into Word documents to create drafts, iterate, and edit.
    • Copilot in Outlook - helps users manage their inbox by analyzing email content and prioritizing the most critical messages.
    • Dynamic 365 Sales - helps businesses close more deals and deepen customer relationships with AI assistance.
    • Dynamic 365 Insights - enables marketers to provide more personalized customer journeys with next-generation AI.
    • Dynamic 365 Customer Service - assists customer service representatives in resolving issues faster using generative AI and automation.

    Pros:

    • Integrates seamlessly with the Microsoft ecosystem.
    • A unified platform that connects various departments, processes, and data.
    • Highly customizable without requiring extensive coding.

    Cons:

    • Complex pricing structure and high costs of ownership.
    • AI capabilities are not natively embedded and come at an extra cost.
    • Steep learning curve due to complex and unintuitive user interface.

    Rating:

    G2: 4.4/5

    4. HubSpot Smart CRM

    HubSpot offers an AI-powered CRM Software with a suite of agentic features under its Breeze Agents branding. These include agents for content generation, prospecting, customer response, and automated insight generation. HubSpot is particularly attractive for small to medium-sized businesses that need fast deployment and tight integration of marketing, sales, and service functions.

    Hubspot Smart CRM

    HubSpot Smart CRM system unifies data, teams, and tools to create a central source of customer intelligence. Breeze Assistant uses the CRM data and connects with the entire business ecosystem to help with meeting prep, content creation, and strategic analysis. Businesses can also combine the Smart CRM with Breeze AI Agents, AI-powered teammates designed to automate work, which can assist with social media, sales prospecting, and customer service.

    Key features:

    • Breeze Assistant - a personal AI-assistant that adapts to an individual's style of work.
    • Customer Agent - automates customer support by responding to typical customer inquiries.
    • Prospecting Agent - supports sales teams by automatically conducting prospect research, identifying buying signals, and crafting personalized email outreach.
    • AI Blog Writer - Creates compelling blog posts with simple prompts.
    • Website Generator - helps create single-page websites with a free AI builder.
    • AI Email Writer - generates sales outreach and marketing emails using generative AI capabilities.
    • Conversation Intelligence - integrates customer feedback into the CRM to enhance team coaching.

    Pros:

    • Seamlessly connects with the whole HubSpot ecosystem.
    • An extensive marketplace of over 1000 third-party apps.
    • Ease of use, configuration, and navigation.
    • Robust reporting capabilities with comprehensive insights into performance.

    Cons:

    • AI capabilities are not natively embedded and come at an extra cost, requiring additional integration.
    • Not suitable for enterprises due to limited customization options and a lack of complex workflows.
    • Advanced features are limited to the higher-priced tiers, increasing the overall costs of ownership.

    Rating:

    G2: 4.4/5

    See also: Top 10 HubSpot Alternatives & Competitors  

    5. Zoho CRM

    Zoho CRM evolved into an AI-driven platform through its Zia suite of agentic capabilities. Zia acts as a built-in AI assistant that goes beyond simple automation to deliver predictive analytics, conversational insights, and autonomous task execution across sales, marketing, and customer support. While Zoho’s multi-agent orchestration is not yet as deep or customizable as enterprise-focused platforms like Creatio or Salesforce, it offers a reliable performance for a wide range of use cases.

    Zoho CRM

    Zia continuously analyzes customer data from emails, calls, website visits, and social interactions to detect patterns, predict outcomes, and recommend the next best action. It can flag anomalies in sales trends, suggest the ideal time to contact a lead, draft email responses, and even interpret sentiment from customer conversations.

    Key features:

    • Zia AI Assistant - offers predictive sales forecasting, anomaly detection, best-time contact suggestions, sentiment analysis, and conversational insights.
    • Sales AI Agents - enable sales teams to automate sales operations, sales coaching, data enrichment, and more.
    • Agent Studio - enables users to create agents by specifying their roles and duties.
    • Zia Module Creation – allows teams to create new modules using simple prompts.
    • Data management and integrity - includes image recognition (Zia Vision), automatic email data capture, and tools to clean and enrich records for more reliable analytics.

    Pros:

    • Seamlessly connects with Zoho applications and a range of third-party tools.
    • Flexible modules and workflow tools allow tailoring to unique business processes.
    • Combines sales, marketing, and support tools in one unified platform.
    • User-friendly interface simplifies the use of the platform.

    Cons:

    • Advanced AI capabilities, such as full predictive analytics, require premium plans.
    • AI agents are only available for sales-related tasks and cannot be extended to marketing or customer service.
    • Limited AI capabilities mean Zoho CRM is not suitable for enterprises.
    • Some users report slower performance when managing large datasets or complex workflows.

    Rating:

    G2: 4.1/5

    See also: Top 10 Zoho CRM Alternatives and Competitors

    Summary

    Agentic CRM represents the new era of customer relationship management, shifting from static data storage to an intelligent, autonomous ecosystem of AI agents that facilitate collaborative workflows in real time. Guided by a central orchestrator, role-based agents handle sales nurturing, marketing optimization, customer service, reporting, and more, sharing data seamlessly and learning from every interaction.

    Among the platforms driving the agentic CRM revolution, Creatio consistently ranks as the top choice, combining deep AI capabilities with exceptional usability and flexibility. Unlike many CRMs that add AI features as optional plug-ins, Creatio natively embeds AI capabilities, which are fundamental to how Creatio's agnostic CRM works.

    Agentic CRM platforms represent the future of customer relationship management, poised to guide modern businesses into an AI-first economy where intelligent automation and autonomous decision-making drive lasting competitive advantage.

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